Back to search

Article

Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese Primates

2025-11-29

Abstract excerpt

<h4>Introductory Paragraph</h4> The melanocortin system plays a central role in regulating hunger and satiety, making it an attractive target for treating metabolic disease. However, the limited clinical success of selective melanocortin-4 receptor (MC4R) agonists prompted the investigation of whether concurrent melanocortin-3 receptor (MC3R) and MC4R activation is key to unlocking the melanocortin system for the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b4dcd78d-298c-5b0a-9fb2-93b2051cb513
DOI
10.1101/2025.11.25.690554
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dual Activation of MC3R and MC4R Drives Weight Loss and Reduces Food Intake in Obese PrimatesDOI 10.1101/2025.11.25.690554
The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.Semantic proximity
The melanocortin receptor MCR4 controls fat consumption.Semantic proximity
Melanocortin pathways: suppressed and stimulated melanocortin-4 receptor (MC4R).Semantic proximity
MC4R in Central and Peripheral SystemsSemantic proximity
Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.Semantic proximity
The Melanocortin System behind the Dysfunctional Eating Behaviors.Semantic proximity
Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity ModelSemantic proximity
The central melanocortin system and human obesity.Semantic proximity
The central melanocortin system and the regulation of energy balance.Semantic proximity
Investigating PYY3-36 and PYY3-36 analogues in the development of an obesity therapySemantic proximity
Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasisSemantic proximity
The MC4 receptor and control of appetite.Semantic proximity
Select a neighboring publication to make it the new centre.