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Article

The melanocortin receptor MCR4 controls fat consumption.

Regulatory peptides - 15 May 2003

Samama Philippe, Rumennik Leonid, Grippo Joseph F

Abstract excerpt

Melanocortins mediate the effects of leptin in the central nervous system (CNS) and regulate energy balance through the MCR3 and MCR4 receptors. Here, we examined the specific role of MCR4 in modulating fat consumption. In a three-choice feeding model, the non-selective melanocortin agonist MT-II decreased fat consumption preferentially and the effect was absent in mice deficient in MCR4. Further, an agonist...

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Identifiers

PMID: 12686465
DOI: 10.1016/s0167-0115(02)00299-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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