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Article

B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.

European journal of immunology - 1 Mar 2016

Carrascal Jorge, Carrillo Jorge, Arpa Berta, Egia-Mendikute Leire, Rosell-Mases Estela, Pujol-Autonell Irma, Planas Raquel, Mora Conchi, Mauricio Dídac, Ampudia Rosa Maria, Vives-Pi Marta, Verdaguer Joan

Abstract excerpt

Autoreactive B lymphocytes play a key role as APCs in diaebetogenesis. However, it remains unclear whether B-cell tolerance is compromised in NOD mice. Here, we describe a new B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse, where the transgenes derive from an islet-infiltrating B lymphocyte of a (8.3-NODxNOR) F1 mouse. The 116C-NOD mouse produces clonal B lymphocytes with pancreatic islet beta cell...

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Identifiers

PMID: 26639224
DOI: 10.1002/eji.201445376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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