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Article

The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2013

Stumpf Melanie, Zhou Xuyu, Bluestone Jeffrey A

Abstract excerpt

The critical role of CTLA-4 in inhibiting Ag-driven T cell responses upon engagement with its ligands, B7-1 and B7-2 and its importance for peripheral T cell tolerance and T cell homeostasis has been studied intensively. The CTLA-4 splice variant ligand-independent (li)-CTLA-4 is expressed in naive and activated T cells and can actively alter T cell signaling despite its lack of a B7 binding domain. To study the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23293354
DOI: 10.4049/jimmunol.1201362
PMCID: PMC3568535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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