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Article

CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L.

Journal of leukocyte biology - 1 Feb 2014

Price Jeffrey D, Beauchamp Nicole M, Rahir Gwendoline, Zhao Yongge, Rieger Cosima C, Lau-Kilby Annie W, Tarbell Kristin V

Abstract excerpt

DCs are important mediators of peripheral tolerance for the prevention of autoimmunity. Chimeric αDEC-205 antibodies with attached antigens allow in vivo antigen-specific stimulation of T cells by CD8(+) DCs, resulting in tolerance in nonautoimmune mice. However, it is not clear whether DC-mediated tolerance induction occurs in the context of ongoing autoimmunity. We assessed the role of CD8(+) DCs in stimulation...

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Source

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Identifiers

PMID: 24082013
DOI: 10.1189/jlb.0113013
PMCID: PMC3896656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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