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Article

Therapeutic potential of tyrosine kinase 2 in autoimmunity.

Expert opinion on therapeutic targets - 1 May 2014

Liang Yan, Zhu Yan, Xia Yi, Peng Hui, Yang Xiao-Ke, Liu Yan-Yan, Xu Wang-Dong, Pan Hai-Feng, Ye Dong-Qing

Abstract excerpt

INTRODUCTION: Tyrosine kinase 2 (Tyk2) is a Janus kinase family member that is crucial for signaling transduction in response to a wide variety of cytokines, including type I IFNs, IL-6, IL-10, IL-12 and IL-23. An appropriate expression of Tyk2-mediated signaling might be essential for maintaining normal immune responses. AREAS COVERED: This review summarizes that Tyk2 is essential for the differentiation and...

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Identifiers

PMID: 24654603
DOI: 10.1517/14728222.2014.892925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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