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Article

Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

21 Aug 2018

Abstract excerpt

TYK2 is a member of the JAK family of tyrosine kinases that is involved in chromosomal translocation-induced fusion proteins found in anaplastic large cell lymphomas (ALCL) that lack rearrangements activating the anaplastic lymphoma kinase (ALK). Here we demonstrate that TYK2 is highly expressed in all cases of human ALCL, and that in a mouse model of NPM-ALK-induced lymphoma, genetic disruption of Tyk2 delays...

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PMID: 30131584
DOI: 10.1038/s41375-018-0239-1

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