Article
Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2013
Li Zhi, Gakovic Milica, Ragimbeau Josiane, Eloranta Maija-Leena, Rönnblom Lars, Michel Frédérique, Pellegrini Sandra
Abstract excerpt
Tyk2 belongs to the Janus protein tyrosine kinase family and is involved in signaling of immunoregulatory cytokines (type I and III IFNs, IL-6, IL-10, and IL-12 families) via its interaction with shared receptor subunits. Depending on the receptor complex, Tyk2 is coactivated with either Jak1 or Jak2, but a detailed molecular characterization of the interplay between the two enzymes is missing. In human...
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