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Article

Egg Activation at Fertilization by a Soluble Sperm Protein

3 Dec 2015

Abstract excerpt

The most fundamental unresolved issue of fertilization is to define how the sperm activates the egg to begin embryo development. Egg activation at fertilization in all species thus far examined is caused by some form of transient increase in the cytoplasmic free Ca(2+) concentration. What has not been clear, however, is precisely how the sperm triggers the large changes in Ca(2+) observed within the egg...

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PMID: 26631595
DOI: 10.1152/physrev.00012.2015

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