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Mammalian Fertilization: From Sperm Factor to Phospholipase Cζ

9 Jan 2004

Abstract excerpt

In mammalian eggs, the fertilizing sperm evokes intracellular Ca2+ ([Ca2+]i) oscillations that are essential for initiation of egg activation and embryonic development. Although the exact mechanism leading to initiation of [Ca2+]i oscillations still remains unclear, accumulating studies suggest that a presently unknown substance, termed sperm factor (SF), is delivered from the fertilizing sperm into the ooplasm...

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PMID: 15093126
DOI: 10.1016/j.biolcel.2003.11.003

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