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Starting a new life: Sperm PLC‐zeta mobilizes the Ca2+ signal that induces egg activation and embryo development

16 Nov 2011

Abstract excerpt

We have discovered that a single sperm protein, phospholipase C-zeta (PLCζ), can stimulate intracellular Ca(2+) signalling in the unfertilized oocyte ('egg') culminating in the initiation of embryonic development. Upon fertilization by a spermatozoon, the earliest observed signalling event in the dormant egg is a large, transient increase in free Ca(2+) concentration. The fertilized egg responds to the...

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PMID: 22086556
DOI: 10.1002/bies.201100127

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