Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammals

9 Feb 2016

Abstract excerpt

A series of intracellular oscillations in the free cytosolic Ca(2+) concentration is responsible for activating mammalian eggs at fertilization, thus initiating embryo development. It has been proposed that the sperm causes these Ca(2+) oscillations after membrane fusion by delivering a soluble protein into the egg cytoplasm. We previously identified sperm-specific phospholipase C (PLC)-ζ as a protein that can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian function and disorders
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26862214
DOI: 10.1042/bst20150221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The sperm phospholipase C-ζ and Ca2+ signalling at fertilization in mammalsPMID 26862214Read ↗

Novel signalling mechanism and clinical applications of sperm-specific PLCζSemantic proximity Read ↗

Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An UpdateSemantic proximity Read ↗

PLCζ, a sperm-specific PLC and its potential role in fertilizationSemantic proximity Read ↗

The role and mechanism of action of sperm PLC-zeta in mammalian fertilisationSemantic proximity Read ↗

Sperm PLCζ: From structure to Ca<sup>2+</sup> oscillations, egg activation and therapeutic potentialSemantic proximity Read ↗

The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCζSemantic proximity Read ↗

PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo developmentSemantic proximity Read ↗

Starting a new life: Sperm PLC‐zeta mobilizes the Ca2+ signal that induces egg activation and embryo developmentSemantic proximity Read ↗

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζSemantic proximity Read ↗

PLCζ and its role as a trigger of development in vertebratesSemantic proximity Read ↗

Molecular Mechanism of Oocyte Activation in Mammals: Past, Present, and Future DirectionsSemantic proximity Read ↗

The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.