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Article

Molecular triggers of egg activation at fertilization in mammals

10 May 2016

Abstract excerpt

In mammals, the sperm activates the development of the egg by triggering a series of oscillations in the cytosolic-free Ca(2+) concentration (Ca(2+) i). The sperm triggers these cytosolic Ca(2+i) oscillations after sperm-egg membrane fusion, as well as after intracytoplasmic sperm injection (ICSI). These Ca(2+) i oscillations are triggered by a protein located inside the sperm. The identity of the sperm protein...

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PMID: 27165049
DOI: 10.1530/rep-16-0123

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