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Article

Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2016

Schwarz Flavio, Springer Stevan A, Altheide Tasha K, Varki Nissi M, Gagneux Pascal, Varki Ajit

Abstract excerpt

The individuals of most vertebrate species die when they can no longer reproduce. Humans are a rare exception, having evolved a prolonged postreproductive lifespan. Elders contribute to cooperative offspring care, assist in foraging, and communicate important ecological and cultural knowledge, increasing the survival of younger individuals. Age-related deterioration of cognitive capacity in humans compromises...

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Identifiers

PMID: 26621708
DOI: 10.1073/pnas.1517951112
PMCID: PMC4711857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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