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Article

Peripheral level of CD33 and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study.

Translational psychiatry - 3 Oct 2022

Gu Xiaojing, Dou Meng, Cao Bei, Jiang Zheng, Chen Yongping

Abstract excerpt

Increased expression of CD33 in the brain has been suggested to be associated with increased amyloid plaque burden, while the peripheral level of CD33 in Alzheimer's disease (AD) patients and its role in AD remain unclear. The current study aimed to systematically explore the bidirectional relationship between peripheral CD33 and AD. Genome-wide association study (GWAS) datasets of AD (Ncases: 21982; Ncontrols:...

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Identifiers

PMID: 36192375
DOI: 10.1038/s41398-022-02205-4
PMCID: PMC9529877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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