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Article

Alzheimer's Disease Risk Variants Interact with Amyloid-Beta to Modulate Monocyte Function.

Cells - 15 Dec 2025

Chatila Zena K, Bradshaw Elizabeth M

Abstract excerpt

While genetics implicate a central role for dysregulated innate immunity in Alzheimer's disease (AD), the contributions of peripheral myeloid cells, such as monocytes, have been largely overlooked in favor of microglia. Here, we investigate whether AD-associated loci, specifically rs3865444 in the CD33 locus and rs1057233 in the SPI1 locus, converge on shared functional pathways in monocytes in the context of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Leukocytes, Mononuclear

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Share to Monocytes

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Share to Sialic Acid Binding Ig-like Lectin 3

Source

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Identifiers

PMID: 41440010
DOI: 10.3390/cells14241990
PMCID: PMC12731656

Genes

CD33
SPI1
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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