Article

Alzheimer’s Disease Risk Variants Interact with Amyloid-beta to Modulate Monocyte Function

2025-11-04

Abstract excerpt

While genetics implicate a central role for dysregulated innate immunity in Alzheimer’s disease (AD), the contributions of peripheral myeloid cells, such as monocytes, have been largely overlooked in favor of microglia. Here, we investigate whether AD associated loci, specifically rs3865444 in the CD33 locus and rs1057233 in the SPI1 locus, converge on shared functional pathways in monocytes in the context of...

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Literature Corpus work: 76e70f7d-6032-5e65-ba18-e4606136a416
DOI: 10.1101/2025.11.02.686117

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