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Article

Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers.

Molecular biology and evolution - 3 Aug 2022

Saha Sudeshna, Khan Naazneen, Comi Troy, Verhagen Andrea, Sasmal Aniruddha, Diaz Sandra, Yu Hai, Chen Xi, Akey Joshua M, Frank Martin, Gagneux Pascal, Varki Ajit

Abstract excerpt

The myelomonocytic receptor CD33 (Siglec-3) inhibits innate immune reactivity by extracellular V-set domain recognition of sialic acid (Sia)-containing "self-associated molecular patterns" (SAMPs). We earlier showed that V-set domain-deficient CD33-variant allele, protective against late-onset Alzheimer's Disease (LOAD), is derived and specific to the hominin lineage. We now report multiple hominin-specific CD33...

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Identifiers

PMID: 35809046
DOI: 10.1093/molbev/msac151
PMCID: PMC9356730

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