Article

Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers

2021-11-26

Abstract excerpt

<h4>Summary</h4> Late-onset Alzheimer’s Disease (LOAD) pathology is rare in our closest living evolutionary relatives (chimpanzees), which also express much lower microglial levels of CD33(Siglec-3)–a myelomonocytic receptor inhibiting innate immune reactivity by extracellular V-set domain recognition of sialic acid(Sia)-containing “self-associated molecular patterns” (SAMPs). We earlier showed that V-set domain-...

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Literature Corpus work: 72f613af-4973-5cbd-a810-9036ebd28c4b
DOI: 10.1101/2021.11.26.470088

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