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Article

Siglec receptors impact mammalian lifespan by modulating oxidative stress.

eLife - 7 Apr 2015

Schwarz Flavio, Pearce Oliver M T, Wang Xiaoxia, Samraj Annie N, Läubli Heinz, Garcia Javier O, Lin Hongqiao, Fu Xiaoming, Garcia-Bingman Andrea, Secrest Patrick, Romanoski Casey E, Heyser Charles, Glass Christopher K, Hazen Stanley L, Varki Nissi, Varki Ajit, Gagneux Pascal

Abstract excerpt

Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number of genes encoding the immunomodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum lifespan in mammals. In keeping...

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Identifiers

PMID: 25846707
DOI: 10.7554/eLife.06184
PMCID: PMC4384638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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