The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study.

doi:10.1186/s12952-015-0039-3

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Article

The rs361525 polymorphism does not increase production of tumor necrosis factor alpha by monocytes from alpha-1 antitrypsin deficient subjects with chronic obstructive pulmonary disease - a pilot study.

Journal of negative results in biomedicine - 1 Dec 2015

Gane Jennie M, Stockley Robert A, Sapey Elizabeth

Abstract excerpt

BACKGROUND: Polymorphisms in the TNF-A gene have been associated with chronic obstructive pulmonary disease (COPD) in some case-control studies. Previous work has shown that COPD/chronic bronchitis subjects with alpha-1 antitrypsin deficiency with the rs361525 TNF-α single nucleotide polymorphism have 100 times more TNF-in spontaneous sputum than disease matched controls. Our objective was to determine if the...

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PMID: 26620975
DOI: 10.1186/s12952-015-0039-3
PMCID: PMC4665865

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