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Article

The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency.

Respiratory research - 11 Jul 2008

Wood Alice M, Simmonds Matthew J, Bayley Darren L, Newby Paul R, Gough Stephen C, Stockley Robert A

Abstract excerpt

BACKGROUND: Genetic variation may underlie phenotypic variation in chronic obstructive pulmonary disease (COPD) in subjects with and without alpha 1 antitrypsin deficiency (AATD). Genotype specific sub-phenotypes are likely and may underlie the poor replication of previous genetic studies. This study investigated subjects with AATD to determine the relationship between specific phenotypes and TNFalpha...

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Share to alpha 1-Antitrypsin
Share to alpha 1-Antitrypsin Deficiency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genetic Predisposition to Disease

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Pulmonary Disease, Chronic Obstructive

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 18620570
DOI: 10.1186/1465-9921-9-52
PMCID: PMC2478658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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