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Article

Tumour necrosis factor-α gene promoter polymorphism in chronic obstructive pulmonary disease

1 Feb 2000

Abstract excerpt

Tumour necrosis factor(TNF)-alpha levels are elevated in airways of patients with chronic obstructive pulmonary disease (COPD) and may contribute to its pathogenesis. A guanine to adenine substitution at position -308 of the TNF-alpha gene promoter (TNF1/2) has been associated with chronic bronchitis of various aetiologies in a Taiwanese population. The authors performed a study investigating association of the...

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PMID: 10706492
DOI: 10.1034/j.1399-3003.2000.15b10.x

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