Article
TNF-alpha promoter polymorphism in relation to TNF-alpha production and clinical status in cystic fibrosis.
Lung - 1 Jan 2000
Schmitt-Grohé Sabina, Stüber Frank, Book Malte, Bargon Joachim, Wagner Thomas O, Naujoks Christian, Schubert Ralf, Lentze Michael J, Zielen Stefan
Abstract excerpt
The severity of lung disease in cystic fibrosis may be related to the genetic propensity of the host to produce tumor necrosis fector alpha (TNF-alpha). A polymorphism in the promoter region of the TNF-alpha gene at nucleotide 308 relative to the transcription start site may be important in determing the host's TNF-alpha response. The aim of this study was to assess the correlation between a TNF-308 promoter...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Female
- Genotype
- Humans
- Infant
- Lipopolysaccharides
- Male
- Polymorphism, Genetic
- Promoter Regions, Genetic