Article
A polymorphism in the promoter region of the human interleukin-16 gene is not associated with asthma or atopy in an Australian population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2005
Akesson L S, Duffy D L, Phelps S C, Thompson P J, Kedda M-A
Abstract excerpt
BACKGROUND: IL-16 is an immunomodulatory cytokine whose expression is increased in the bronchial mucosa, bronchoalveolar lavage fluid and induced sputum of asthmatic patients. It has been suggested that IL-16 has a regulatory role in the pathophysiology of asthma. A single-nucleotide polymorphism (T(-295)C) has been described in the promoter region of the gene and it has been hypothesized that this polymorphism...
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