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Article

Regulation of tumor necrosis factor secretion in leukocytes from alpha-1-antitrypsin deficient humans.

Immunological investigations - 1 Jan 2000

Scuderi P, Finley P R, Shon B Y, Udall J N, Roe D J, Chong A S

Abstract excerpt

Alpha-1-antitrypsin (AT) is one of several alpha-globulins which have been shown to be inhibitors of human peripheral blood monocyte TNF secretion in vitro. AT deficiency states exist, within which individuals of either the PiSS or PiZZ phenotype have reduced hepatocyte and mononuclear phagocyte AT secretion when compared to normal PiMM subjects. Here we have compared the capacity of peripheral blood monocytes of...

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PMID: 1705919
DOI: 10.3109/08820139009052972

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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