Article
Regulation of tumor necrosis factor secretion in leukocytes from alpha-1-antitrypsin deficient humans.
Immunological investigations - 1 Jan 2000
Scuderi P, Finley P R, Shon B Y, Udall J N, Roe D J, Chong A S
Abstract excerpt
Alpha-1-antitrypsin (AT) is one of several alpha-globulins which have been shown to be inhibitors of human peripheral blood monocyte TNF secretion in vitro. AT deficiency states exist, within which individuals of either the PiSS or PiZZ phenotype have reduced hepatocyte and mononuclear phagocyte...
Topics
- Adult
- Aged
- Alpha-Globulins
- Cells, Cultured
- Cytokines
- Humans
- Lipopolysaccharides
- Middle Aged
- Monocytes
- Phenotype
- Transforming Growth Factor alpha
- Tumor Necrosis Factor-alpha
- alpha 1-Antitrypsin
- alpha 1-Antitrypsin Deficiency