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Article

Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease.

Respiratory research - 1 Jan 2002

Küçükaycan Mehmet, Van Krugten Michiel, Pennings Herman-Jan, Huizinga Tom W J, Buurman Wim A, Dentener Mieke A, Wouters Emiel F M

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory process, in which the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-alpha is considered to play a role. In the present study the putative involvement of TNF-alpha gene polymorphisms in pathogenesis of COPD was studied by analysis of four TNF-alpha gene polymorphisms in a Caucasian COPD population. METHODS:...

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Identifiers

PMID: 12537602
DOI: 10.1186/rr194
PMCID: PMC150514

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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