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Article

Tumor necrosis factor-{alpha} rs361525 polymorphism is associated with increased local production and downstream inflammation in chronic obstructive pulmonary disease.

American journal of respiratory and critical care medicine - 15 Jul 2010

Sapey Elizabeth, Wood Alice M, Ahmad Ali, Stockley Robert A

Abstract excerpt

RATIONALE: Chronic obstructive pulmonary disease (COPD) has a genetic component, explaining susceptibility. Tumor necrosis factor (TNF)-alpha polymorphisms have been associated with COPD, but it is unclear if genotype influences clinical phenotype, protein expression, and bioactivity. OBJECTIVES: To determine if a functional polymorphism was important by assessing TNF-alpha expression and activity and its...

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Identifiers

PMID: 20299531
DOI: 10.1164/rccm.200912-1846OC

Genes

TNF
FEV

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