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Article

Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues

28 Nov 2015

Abstract excerpt

The elderly immune system is characterized by reduced responses to infections and vaccines, and an increase in the incidence of autoimmune diseases and cancer. Age-related deficits in the immune system may be caused by peripheral homeostatic pressures that limit bone marrow B-cell production or migration to the peripheral lymphoid tissues. Studies of peripheral blood B-cell receptor spectratypes have shown that...

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PMID: 26614343
DOI: 10.1002/eji.201545586

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