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The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

28 Aug 2019

Abstract excerpt

BACKGROUND: Aging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologically healthy individuals in four age categories (range 20-95y) via multi-parameter flow cytometry. Furthermore, we studied the naive and antigen-experienced B cell receptor (BCR) repertoire of...

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PMID: 31485252
DOI: 10.1186/s12979-019-0163-x

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