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Article

Phylogenetic analysis of the human antibody repertoire reveals quantitative signatures of immune senescence and aging.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2017

de Bourcy Charles F A, Angel Cesar J Lopez, Vollmers Christopher, Dekker Cornelia L, Davis Mark M, Quake Stephen R

Abstract excerpt

The elderly have reduced humoral immunity, as manifested by increased susceptibility to infections and impaired vaccine responses. To investigate the effects of aging on B-cell receptor (BCR) repertoire evolution during an immunological challenge, we used a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and elderly individuals before and after influenza vaccination. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

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Source

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Identifiers

PMID: 28096374
DOI: 10.1073/pnas.1617959114
PMCID: PMC5293037

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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