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Article

High-throughput sequencing insights into T-cell receptor repertoire diversity in aging.

Genome medicine - 19 Nov 2015

Goronzy Jörg J, Qi Qian, Olshen Richard A, Weyand Cornelia M

Abstract excerpt

Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.

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Share to Aging
Share to Clone Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Receptors, Antigen, T-Cell

Share to Single-cell and spatial transcriptomics

Share to T-Lymphocytes

Source

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Identifiers

PMID: 26582264
DOI: 10.1186/s13073-015-0242-3
PMCID: PMC4652363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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