Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence

Abstract excerpt

<h4>ABSTRACT</h4> Immunosenescence, a major hallmark of systemic aging, refers to the progressive functional decline of the immune system. This decline not only compromises host defense and immunological memory but also fuels chronic inflammation and tissue degeneration (collectively known as inflammaging). While single-cell RNA sequencing (scRNA-seq) has revealed transcriptomic alterations in immune aging, analy...

Topics

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• CAR-T cell therapy research
• COVID-19 Clinical Research Studies
• Cytomegalovirus and herpesvirus research
• Immune Cell Function and Interaction
• Immune responses and vaccinations
• Neuroinflammation and Neurodegeneration Mechanisms
• Single-cell and spatial transcriptomics
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

7a86f67c-d6ad-5495-8e39-88c99606d2d7

DOI

10.1101/2025.11.21.689731