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Article

Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age.

Frontiers in immunology - 1 Jan 2020

Ghraichy Marie, Galson Jacob D, Kovaltsuk Aleksandr, von Niederhäusern Valentin, Pachlopnik Schmid Jana, Recher Mike, Jauch Annaïse J, Miho Enkelejda, Kelly Dominic F, Deane Charlotte M, Trück Johannes

Abstract excerpt

B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires. The most significant changes were observed in the first 10 years of life, and were characterized by altered...

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Identifiers

PMID: 32849618
DOI: 10.3389/fimmu.2020.01734
PMCID: PMC7424015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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