Article

Maturation of the human B-cell receptor repertoire with age

2019-04-16

Abstract excerpt

B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B-cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced B-cell receptor (BCR) repertoires. The most significant changes were observed in the first 10 years of life, and were characterized by altered immunoglobulin gene us...

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Literature Corpus work: c83e5227-7ba2-54c7-b3cc-851f6ac9418c
DOI: 10.1101/609651

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