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Article

Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2014

Wang Chen, Liu Yi, Xu Lan T, Jackson Katherine J L, Roskin Krishna M, Pham Tho D, Laserson Jonathan, Marshall Eleanor L, Seo Katie, Lee Ji-Yeun, Furman David, Koller Daphne, Dekker Cornelia L, Davis Mark M, Fire Andrew Z, Boyd Scott D

Abstract excerpt

Elderly humans show decreased humoral immunity to pathogens and vaccines, yet the effects of aging on B cells are not fully known. Chronic viral infection by CMV is implicated as a driver of clonal T cell proliferations in some aging humans, but whether CMV or EBV infection contributes to alterat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24337376
DOI: 10.4049/jimmunol.1301384
PMCID: PMC3947124

Genes

BCR
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24337376-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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