Article

Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice

2020-05-05

Abstract excerpt

Neuroinflammation plays a crucial role during ageing and various neurological conditions, including Alzheimer’s disease, multiple sclerosis and infection. Technical limitations, however, have prevented an integrative analysis of how lymphocyte immune receptor repertoires and their accompanying transcriptional states change with age in the central nervous system (CNS). Here, we leveraged single-cell sequencing to s...

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Literature Corpus work: 9cfa82a0-3f2a-5973-9fd4-e7501e2ab249
DOI: 10.1101/2020.05.04.077081

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