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Article

In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation.

Blood - 15 Mar 2007

Nguyen Vu H, Zeiser Robert, Dasilva Daniel L, Chang Daisy S, Beilhack Andreas, Contag Christopher H, Negrin Robert S

Abstract excerpt

CD4(+)CD25(+) regulatory T cells (Tregs) suppress immune responses to alloantigens. The in vivo circulation and tissue localization of Tregs during an adaptive immune response remain unclear. We noninvasively tracked luciferase-expressing Tregs over time in an allogeneic bone marrow transplant model and demonstrated colocalization with effector T cells and initial expansion in secondary lymphoid organs before...

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Source

Identifiers

PMID: 17095616
DOI: 10.1182/blood-2006-08-044529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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