Article
TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice.
European journal of immunology - 1 May 2015
Bergot Anne-Sophie, Chaara Wahiba, Ruggiero Eliana, Mariotti-Ferrandiz Encarnita, Dulauroy Sophie, Schmidt Manfred, von Kalle Christof, Six Adrien, Klatzmann David
Abstract excerpt
Analyses of the regulatory T (Treg) cell TCR repertoire should help elucidate the nature and diversity of their cognate antigens and thus how Treg cells protect us from autoimmune diseases. We earlier identified CD44(hi) CD62L(low) activated/memory (am) Treg cells as a Treg-cell subset with a high turnover and possible self-specificity. We now report that amTreg cells are predominantly distributed in lymph nodes...
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