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Article

Cutting Edge: Recruitment, Retention, and Migration Underpin Functional Phenotypic Heterogeneity of Regulatory T Cells in Tumors.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2021

Ikebuchi Ryoyo, Moriya Taiki, Ueda Mizuki, Yasuda Ippei, Kusumoto Yutaka, Chtanova Tatyana, Tomura Michio

Abstract excerpt

Tumor-infiltrating regulatory T cells (Tregs) have been extensively studied as therapeutic targets. However, not all infiltrating T cells exert their functions equally, presumably because of their heterogeneity and substantial turnover in tissues. In this study, we hypothesized that intertissue migration underlies the functional heterogeneity of Tregs. To test this, we applied in vivo photolabeling to examine...

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Identifiers

PMID: 34290103
DOI: 10.4049/jimmunol.2001083

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