Article

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells

2026-07-16

Abstract excerpt

<title>Abstract</title> <p> How the immune system surveys nascent tumors and how this surveillance is subverted remain poorly understood. Using high-plex cyclic immunofluorescence and 3D imaging, we identified regulatory T (Treg) cells that co-localize with tissue-resident memory (T <sub>RM</sub> )-like T cells in early-stage human melanoma. In an autochthonous Braf/PTEN melanoma model expressing a defined tum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c2b336b-3e4a-51c3-a2c6-d07bf725b939
DOI: 10.21203/rs.3.rs-8554735/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cellsDOI 10.21203/rs.3.rs-8554735/v1Read

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cellsSemantic proximity Read

Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis.Semantic proximity Read

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human MelanomaSemantic proximity Read

Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human MelanomaSemantic proximity Read

Cellular interactions in the sentinel lymph node predict melanoma recurrenceSemantic proximity Read

Circulating and brain-resident memory CD8+ T cells seed distinct bystander T <sub>RM</sub> -like populations in glioblastomaSemantic proximity Read

Tissue-resident memory T cell signatures from single-cell analysis associated with better melanoma prognosisSemantic proximity Read

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanomaSemantic proximity Read

Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.Semantic proximity Read

Mapping the immune landscape in metastatic melanoma reveals localized cell-cell interactions correlating to immunotherapy responsivenessSemantic proximity Read

Temporal genomic analysis of melanoma rejection identifies regulators of tumor immune evasionSemantic proximity Read

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39Semantic proximity Read