Article

The initial melanoma T cell infiltrate is defined by tissue-resident programs restrained by regulatory T cells

2025-10-22

Abstract excerpt

How the immune system surveys nascent tumors and how this surveillance is subverted remain poorly understood. Using high-plex cyclic immunofluorescence and 3D imaging, we identified regulatory T (Treg) cells that co-localize with tissue-resident memory (T RM )-like T cells in early-stage human melanoma. In an autochthonous Braf/PTEN melanoma model expressing a defined tumor antigen, the initial CD8 + T cell infi...

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Literature Corpus work: a1edadfe-0670-5bf3-b9b0-68d73583dfb7
DOI: 10.1101/2025.10.21.683143

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