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Article

Oxidative Stress in Fanconi Anemia Hematopoiesis and Disease Progression

16 Jul 2008

Abstract excerpt

Patients with the genomic instability syndrome Fanconi anemia (FA) commonly develop progressive bone marrow failure and have a high risk of cancer. The prominent role of the FA protein family involves DNA damage response and/or repair. Oxidative stress, defined as an imbalance between the production of reactive oxygen species and antioxidant defense, is considered to be an important pathogenic factor in...

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PMID: 18627348
DOI: 10.1089/ars.2008.2129

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