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Article

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.

Scientific reports - 13 Dec 2019

Pan Xiaolei, Chen Yun, Biju Beena, Ahmed Naveed, Kong Joyce, Goldenberg Marti, Huang Judy, Mohan Nandakumar, Klosek Stephanie, Parsa Kian, Guh Chia-Yu, Lu Robert, Pickett Hilda A, Chu Hsueh-Ping, Zhang Dong

Abstract excerpt

Cancer cells maintain their telomeres by either re-activating telomerase or adopting the homologous recombination (HR)-based Alternative Lengthening of Telomere (ALT) pathway. Among the many prominent features of ALT cells, C-circles (CC) formation is considered to be the most specific and quantifiable biomarker of ALT. However, the molecular mechanism behind the initiation and maintenance of CC formation in ALT...

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Identifiers

PMID: 31836759
DOI: 10.1038/s41598-019-55537-5
PMCID: PMC6911001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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