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Article

SARM modulates MyD88-mediated TLR activation through BB-loop dependent TIR-TIR interactions.

Biochimica et biophysica acta - 1 Feb 2016

Carlsson Emil, Ding Jeak Ling, Byrne Bernadette

Abstract excerpt

Toll-like receptors (TLRs) recognise invading pathogens and initiate an innate immune response by recruiting intracellular adaptor proteins via heterotypic Toll/interleukin-1 receptor (TIR) domain interactions. Of the five TIR domain-containing adaptor proteins identified, Sterile α- and armadillo-motif-containing protein (SARM) is functionally unique; suppressing immune signalling instead of promoting it. Here...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26592460
DOI: 10.1016/j.bbamcr.2015.11.021

Genes

LTA
TLR2
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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