Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

The Journal of biological chemistry - 4 Sept 2009

Verstak Brett, Nagpal Kamalpreet, Bottomley Stephen P, Golenbock Douglas T, Hertzog Paul J, Mansell Ashley

Abstract excerpt

Toll/interleukin-1 (TIR)receptor-containing adapters are critical in orchestrating the different signal transduction pathways following Toll-like receptor (TLR) activation. MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling in response to bacterial infection. We have previously reported an interaction between Mal and tumor necrosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Differentiation Factor 88

Share to NF-kappa B

Share to Receptors, Interleukin-1

Share to TNF Receptor-Associated Factor 6

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 19592497
DOI: 10.1074/jbc.M109.023044
PMCID: PMC2782013

Genes

TRAF6
TLR4
TLR2
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.PMID 19592497Read ↗

Mal, more than a bridge to MyD88Semantic proximity Read ↗

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.Semantic proximity Read ↗

TIRAP: an adapter molecule in the Toll signaling pathway.Semantic proximity Read ↗

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.Semantic proximity Read ↗

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 SignalingSemantic proximity Read ↗

Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).Semantic proximity Read ↗

Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway.Semantic proximity Read ↗

Signalling, sorting and scaffolding adaptors for Toll-like receptorsSemantic proximity Read ↗

Toll-Like Receptor Signaling Pathways—Therapeutic OpportunitiesSemantic proximity Read ↗

Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets.Semantic proximity Read ↗

Paradoxical Roles of the MAL/Tirap Adaptor in PathologiesSemantic proximity Read ↗

TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.