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Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities

1 Jan 2010

Abstract excerpt

Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity. Various adaptor proteins, including MyD88, IRAKs,...

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PMID: 20981241
DOI: 10.1155/2010/781235

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