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Article

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.

The Journal of biological chemistry - 2 May 2008

Nyman Tomas, Stenmark Pål, Flodin Susanne, Johansson Ida, Hammarström Martin, Nordlund Pär

Abstract excerpt

The Toll/interleukin-1 receptor (TIR) domain is a highly conserved signaling domain found in the intracellular regions of Toll-like receptors (TLRs), in interleukin-1 receptors, and in several cytoplasmic adaptor proteins. TIR domains mediate receptor signal transduction through recruitment of adaptor proteins and play critical roles in the innate immune response and inflammation. This work presents the 2.2A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18332149
DOI: 10.1074/jbc.C800001200

Genes

TLR10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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