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Article

The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.

The Journal of biological chemistry - 2 May 2008

Nyman Tomas, Stenmark Pål, Flodin Susanne, Johansson Ida, Hammarström Martin, Nordlund Pär

Abstract excerpt

The Toll/interleukin-1 receptor (TIR) domain is a highly conserved signaling domain found in the intracellular regions of Toll-like receptors (TLRs), in interleukin-1 receptors, and in several cytoplasmic adaptor proteins. TIR domains mediate receptor signal transduction through recruitment of ad...

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Share to Conserved Sequence
Share to Crystallography, X-Ray
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

Share to Protein Structure, Tertiary

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Source

Identifiers

PMID: 18332149
DOI: 10.1074/jbc.C800001200

Genes

TLR10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18332149-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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