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Article

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

2 Apr 2012

Abstract excerpt

MyD88 adaptor-like protein (Mal) is a crucial adaptor that acts as a bridge to recruit the MyD88 molecule to activated TLR4 receptors in response to invading pathogens. The specific assembly of the Toll/interleukin-1 receptor (TIR) domains of TLR4, Mal and MyD88 is responsible for proper signal transduction in the TLR4 signaling pathway. However, the molecular mechanism for the specificity of these TIR domains...

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PMID: 22485159
DOI: 10.1371/journal.pone.0034202

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