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Signalling, sorting and scaffolding adaptors for Toll-like receptors

30 Dec 2019

Abstract excerpt

Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or disease settings. Activation of TLRs by pathogen- and/or host-derived stimuli triggers a range of signalling and transcriptional pathways to programme inflammatory and anti-microbial responses, including the production of a suite of...

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PMID: 31889021
DOI: 10.1242/jcs.239194

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